Will your statin drug kill you? Is vitamin D a better choice for preventing heart disease?

Drs BA Golomb and MA Evans recently wrote a review of the many papers that dealt with the adverse effects of statins, an immensely popular (and profitable) class of drugs that lowers blood cholesterol levels.[1] One of the potential little side effects is rhabdomyolysis, a devastating muscle-wasting disease described by Stedman’s Medical dictionary as “an acute, fulminant, potentially fatal disease that destroys skeletal muscle and is often accompanied by the excretion of myoglobin in the urine.” Others side effects are cognitive loss (decreased ability to think soundly), neuropathy (nerve deterioration), pancreatic and liver dysfunction and sexual dysfunction. The authors also mentioned that most physicians are unaware of these problems.

I recently commissioned research that shows that most physicians, as well as their patients are woefully ignorant of the importance of vitamin D. So how do the two tie together? In an earlier post on heart disease, I cited the research by Dr Ed Giovannucci and his colleagues at Harvard.[2] They showed that men with the lowest levels of serum (blood) vitamin D were about 2.4 times as likely to suffer a heart attack as those whose levels were highest. They also showed that those with the lowest vitamin D levels also had the lowest HDL, the “good cholesterol.” As also pointed out in my earlier blogs, vitamin D has the ability to reduce arterial calcification and reduce inflammation, both risk factors for heart disease.

Vitamin D also increases muscle strength rather than reducing it and increases fertility in men and women as well as protecting the nervous system and enhancing cognitive abilities. This can all be done for about $15 per year worth of supplementation, and sunlight is free. Compare that to the thousands of dollars required to poison oneself with statin drugs. Which way would you like to bet? Remember to check with your doctor before reducing or changing medications, as withdrawal could also be dangerous. Meanwhile, stop eating junk food and get some healthful outdoor exercise!

[1] Golomb BA, Evans MA. Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs. 2008;8(6):373-418.
[2] Giovannucci, E. et al. 25-hydroxy-vitamin D and risk of myocardial infarction in men. Ann Intern Med 2008;168:1174-80.

Losing your mind: Is Alzheimer’s disease in your future or your parents’ future? Can sunlight and vitamin D prevent it?

I have previously posted regarding the effect of vitamin D on cognitive disability, autism and other brain disorders. With all of these disorders, there is a clear correlation between sunlight and/or vitamin D deficiency and decreased brain function. Considering that most elderly people are severely vitamin D deficient and that there are vitamin D receptors throughout the brain, it would not be surprising to also find the same correlation with Alzheimer’s, which is a brain disease. An excellent paper by Dr Frederick Dyer[1] makes a case that Alzheimer’s is, at least in part, a vitamin D-deficiency disease.

Dr Dyer makes the point that many diseases or disorders—those that are well-established as correlating to vitamin D deficiency—are themselves risk factors for Alzheimer’s. These include depression, osteoporosis, diabetes, poor cognitive abilities, periodontal disease, dental caries, inflammation, tooth loss, low cognitive performance, poor strength, depression, congestive heart failure, peripheral artery disease, hypertension and arterial plaque. In other words, Alzheimer’s shows a "co-morbidity” with these disorders, meaning that they may have the same underlying causes. Lack of sunlight/vitamin D is likely one of those causes.

Until we know for sure, it is certainly a great idea to maintain high levels of vitamin D in ourselves and in our aging parents; there is no downside, and it may prevent us from losing our minds.

Another excellent paper on vitamin D and Alzheimer’s will be published soon; I will keep you posted.

[1] Dyer, F. Deficient Vitamin D in the Pathogenesis of Alzheimer’s Disease. Unpublished manuscript furnished to author December 2008. Used by permission.

Can vitamin D and Sunlight make you smarter?

The preponderance of evidence suggests that higher blood levels of vitamin D correlate to better cognitive ability (ability to think), so if you want a higher IQ, it behooves you to keep your vitamin D levels high. In the winter in the Northern US, Northern Europe, Canada and other high-latitude countries, this may mean supplementing with 3,000-5,000 IU daily for most people and up to 6,400 IU daily for nursing mothers.[1] Another alternative is to use a tanning bed two or three times weekly or take frequent tropical vacations (unless you have type-one skin that does not tan—never burn).

The latest scientific paper on cognitive abilities as compared to vitamin D levels shows that persons who have the lowest levels are more than twice as likely to be cognitively impaired as those with the highest levels.[2] I was not surprised at the results of this study; in my book, I had documented other research indicating that in elderly people with the highest levels of vitamin D scored 3-5 times higher on two cognitive tests than those with the lowest levels.[3] Those with the lowest levels were also 12 times as likely to be depressed.

When we consider that vitamin D is absolutely essential to proper nerve function and development,[4] [5] and that there are vitamin D receptors throughout the central nervous system,[6] it stands to reason that mental abilities would be compromised by poor vitamin D status. It also follows that depression would be higher in those whose levels are low. Therefore, it follows that sunlight and vitamin D may make you both smarter and happier.

[1] Wagner C. et al. High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study. Breastfeed Med 2006;1:59-70.
[2] Llewellyn, D. et al. Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment. J Geriatr Psychiatry Neurol Online. December 10, 2008.
[3] Wilkins C. et al. Vitamin D Deficiency Is Associated With Low Mood and Worse Cognitive Performance in Older Adults. Am J Geriatr Psychiatry;2006;14:1032–1040).
[4] McCann J. et al. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain
dysfunction? FASEB J. 2008;22:982-1001.
[5] Carlson, A. et al. Is vitamin D deficiency associated with peripheral neuropathy? The Endocrinologist 2007;17:319-25.
[6] McCann J. et al. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain
dysfunction? FASEB J. 2008;22:982-1001.